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KMID : 0043320030260110887
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Archives of Pharmacal Research
2003 Volume.26 No. 11 p.887 ~ p.891
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Synthesis and Antiviral Activity of Novel trans-2,2-Dimethyl Cyclopropyl Nucleosides
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Kook Min-Chul
Choi Bo-Gil
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Abstract
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Novel trans-2,2-dimethylcyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate, 3, was synthesized via five steps from ethyl chrysanthemate and condensed with purine bases using the Mitsunobu reaction to give six cyclopropyl nucleosides. These synthesized nucleosides did not show any significant antiviral activity against HSV-1, HSV-2, EMCV, Cox B3, or VSV, at concentrations up to 100 .
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KEYWORD
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2,2-Dimethylcyclopropyl nucleoside, Antiviral agent, Ethyl chrysanthemate
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